High-Throughput Sequencing and Estimated Relapse Risk in Patients With Sézary Syndrome

Jeffrey D. Weiner; David M. Weiner; Bernice M. Benoit; Jessica E. Teague; Rachael A. Clark; Alain H. Rook

doi:10.1001/jamadermatol.2025.3054

September 3, 2025JAMA Dermatology

High-Throughput Sequencing and Estimated Relapse Risk in Patients With Sézary Syndrome

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Key Points

Estimated relapse risk with high-throughput sequencing shows potential for improved patient management.
Key evidence includes the successful assessment of T-cell receptors in patients with Sézary syndrome.
Observational analysis utilizes high-throughput sequencing to estimate the relapse risk of T-cell receptors.
Findings highlight the need for improved monitoring strategies for patients with Sézary syndrome.

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Implication

Cohort study examines high-throughput sequencing of T-cell receptors to assess relapse risk in Sézary syndrome patients.

Abstract

This cohort study examines high-throughput sequencing of the T-cell receptor to estimate relapse risk in patients with Sézary syndrome in clinical remission.

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Weiner et al. (2025) studied this question.

synapsesocial.com/papers/68c1840e9b7b07f3a06106c2 https://doi.org/10.1001/jamadermatol.2025.3054

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High-Throughput Sequencing and Estimated Relapse Risk in Patients With Sézary Syndrome

Key Points

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Implication

Abstract

Discussion

Cite This Study

High-Throughput Sequencing and Estimated Relapse Risk in Patients With Sézary Syndrome

Key Points

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Implication

Abstract

Discussion

Cite This Study

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