Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 19, 2026CureusOpen Access

Flow Cytometry for Diagnosing Sézary Syndrome When Skin Biopsies Are Inconclusive: A Case Report

View Full Paper
Ask AI
Bookmark
Share

Authors

AMAbdelhafid El MrahiMohamed I UniversitySDSouha DennaMohamed I UniversityMBM. BensalahMohamed I University

Discussion

Loading...

Member takes

Implication

Case report highlights flow cytometry identifying Sézary syndrome in a patient with inconclusive biopsies, suggesting improved diagnostics.

Key Points

  • To demonstrate the utility of flow cytometry in diagnosing Sézary syndrome when skin biopsies do not provide conclusive results.
  • Utilized peripheral blood flow cytometry to analyze T-cell populations.
  • Performed T-cell receptor beta-chain constant region 1 (TRBC1) expression analysis.
  • Assessed circulating Sézary cells in blood samples.
  • Conducted TNMB staging for classification of disease.
  • Implemented peginterferon alfa-2a treatment alongside supportive care.
  • Flow cytometry identified an aberrant CD4+ T-cell population constituting 90% of lymphocytes.
  • Confirmed monoclonality through TRBC1 positivity in the identified T-cells.
  • Patient received TNMB classification as T4N3M0B2 (stage IVA2).
  • Clinical and laboratory improvement observed following treatment initiation.
  • Demonstrated that early flow cytometry can reduce diagnosis delays and enhance treatment response monitoring.

Cite This Study

Mrahi et al. (2026) studied this question.

synapsesocial.com/papers/69e4739a010ef96374d8f529https://doi.org/10.7759/cureus.107213
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of Sézary cell marker expression and cell death behaviour upon in vitro treatment by flow cytometry in Sézary syndrome patients2024 · 3 citations
  2. 2Real-Life Barriers to Diagnosis of Early Mycosis Fungoides: An International Expert Panel Discussion2022 · 47 citations
  3. 3Sézary syndrome and mycosis fungoides: An overview, including the role of immunophenotyping2020 · 50 citations
  4. 4Mycosis fungoides and Sézary syndrome: clinical, histopathological and immunohistochemical review and update2012 · 82 citations