What question did this study set out to answer?

To assess the diagnostic and prognostic value of a simplified flow cytometric panel measuring CD3, CD4, CD26, and CD7 in mycosis fungoides and Sézary syndrome.

November 17, 2011American Journal of Clinical PathologyOpen Access

Simplified Flow Cytometric Assessment in Mycosis Fungoides and Sézary Syndrome

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Authors

AHAlexandra C. Hristov EVEric C. Vonderheid MBMichael J. Borowitz

Discussion

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Overview

Cohort study reveals abnormal T-cell counts correlate with disease severity in mycosis fungoides and Sézary syndrome, indicating flow cytometry aids prognosis.

Key Points

To assess the diagnostic and prognostic value of a simplified flow cytometric panel measuring CD3, CD4, CD26, and CD7 in mycosis fungoides and Sézary syndrome.
Analyzed peripheral blood samples from 109 subjects: 69 with mycosis fungoides/Sézary syndrome, 31 hospitalized controls, and 9 with inflammatory skin disease.
Identified quantitative abnormalities (>15% CD26- or CD7- T cells) and phenotypic abnormalities (CD26- or CD7- with aberrant CD3, CD4, or CD7 expression) across a median follow-up of 82 months.
Abnormal T-cell populations were detected in 46% of patients with mycosis fungoides/Sézary syndrome (32/69) and correlated significantly with clinical disease extent.
Quantitative abnormalities occurred more frequently than phenotypic abnormalities, and CD4+/CD26- cells were more common and better correlated with disease extent than CD4+/CD7- cells.
Progressive increases in circulating abnormal T cells were associated with worsening clinical disease.

Cite This Study

Hristov et al. (2011) studied this question.

synapsesocial.com/papers/6a02a32f67f6ea5cc875509e https://doi.org/10.1309/ajcp09otjoyavzzk

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November 17, 2011American Journal of Clinical PathologyOpen Access

Simplified Flow Cytometric Assessment in Mycosis Fungoides and Sézary Syndrome

View Full Paper

Ask AI

Bookmark

Authors

AHAlexandra C. Hristov EVEric C. Vonderheid MBMichael J. Borowitz

Discussion

Member takes

Overview

Cohort study reveals abnormal T-cell counts correlate with disease severity in mycosis fungoides and Sézary syndrome, indicating flow cytometry aids prognosis.

Key Points

To assess the diagnostic and prognostic value of a simplified flow cytometric panel measuring CD3, CD4, CD26, and CD7 in mycosis fungoides and Sézary syndrome.
Analyzed peripheral blood samples from 109 subjects: 69 with mycosis fungoides/Sézary syndrome, 31 hospitalized controls, and 9 with inflammatory skin disease.
Identified quantitative abnormalities (>15% CD26- or CD7- T cells) and phenotypic abnormalities (CD26- or CD7- with aberrant CD3, CD4, or CD7 expression) across a median follow-up of 82 months.
Abnormal T-cell populations were detected in 46% of patients with mycosis fungoides/Sézary syndrome (32/69) and correlated significantly with clinical disease extent.
Quantitative abnormalities occurred more frequently than phenotypic abnormalities, and CD4+/CD26- cells were more common and better correlated with disease extent than CD4+/CD7- cells.
Progressive increases in circulating abnormal T cells were associated with worsening clinical disease.

Cite This Study

Hristov et al. (2011) studied this question.

synapsesocial.com/papers/6a02a32f67f6ea5cc875509e https://doi.org/10.1309/ajcp09otjoyavzzk

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