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September 20, 2025American Journal of Clinical Pathology

Expanded CD4+CD57+ T-large granular lymphocytes: A diagnostic pitfall in blood staging of mycosis fungoides/Sézary syndrome

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Authors

YZYumeng ZhangDQDahui QinOOOluwatobi Ozoya

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Overview

Case analysis reveals challenges in accurately diagnosing mycosis fungoides through blood staging, pointing to T-LGL complexities.

Key Points

  • Patients with expanded T-large granular lymphocyte populations were misclassified as malignant, impacting treatment plans.
  • Three cases with discordant T-cell receptor profiles were observed, suggesting reactive rather than malignant growth.
  • An analysis of 100 blood flow cytometry panels showed similar T-LGL populations, complicating diagnosis in some patients.
  • Comprehensive molecular profiling helps ensure accurate disease assessment, supporting effective management of MF/SS.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68d469ba31b076d99fa65fe6https://doi.org/10.1093/ajcp/aqaf097
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Simplified Flow Cytometric Assessment in Mycosis Fungoides and Sézary Syndrome2011 · 72 citations
  2. 2Laboratory Evaluation of Peripheral Blood Involvement in Mycosis Fungoides and Sézary Syndrome: Evolution of Flow Cytometry and Morphology Quantification and Interpretation2026 · 3 citations
  3. 3Flow Cytometry for Diagnosing Sézary Syndrome When Skin Biopsies Are Inconclusive: A Case Report2026
  4. 4Heterogeneity of circulating CD57+ cytotoxic cell subsets across disease stage and aggressiveness in cutaneous T cell lymphoma2025
  5. 5Dissecting Immune Determinants in Lesional Skin of Cutaneous T-Cell Lymphoma During Mogamulizumab Therapy2026