Cobalt-Catalyzed Cross-Electrophile Dehydroxylative and Desulfonylative Allylation

Herein, we report a step- and atom-economical allylation reaction of allyl alcohols with activated alkyl bromides by merging cross-electrophile and dehydroxylative coupling under the catalysis of cobalt. This reaction delivers a method to synthesize multisubstituted γ,δ-unsaturated α,α-difluoro amides and carboxylates in a highly regio- and diastereoselective manner. Furthermore, we also demonstrate the viability of a cobalt-catalyzed cross-electrophile desulfonylative allylation in a proof-of-concept study.