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September 10, 2025VirulenceOpen Access

The bittersweet link between glucose metabolism, cellular microenvironment and viral infection

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Viruses manipulate glucose metabolism to promote their replication and evade the immune response.
Alterations in glycolytic flux and key enzymes like hexokinase impact immune cell activation and cytokine production.
Metabolic changes create a bidirectional interaction that may yield antiviral responses alongside pathogenic virus survival.
Understanding the interplay between glucose metabolism and viral infection can inform targeted antiviral strategies.

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This review demonstrates how viral infections alter glucose metabolism and immune responses, highlighting metabolic pathways exploited by viruses.

Liu et al. (2025) studied this question.

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This review demonstrates how viral infections alter glucose metabolism and immune responses, highlighting metabolic pathways exploited by viruses.