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Exploration of the distribution of intestinal bacteria in mice under normal and intestinal leakage (IBD) conditions

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This research shows bacterial translocation under intestinal leakage in mice, highlighting microbial community dynamics.

Compromised intestinal barrier significantly increases microbial translocation to blood and organs.
In IBD mice, levels of ZO-1 and occludin proteins are decreased compared to normal controls.
GFP-labelled Escherichia coli was used to trace bacterial distribution post-leakage.
Findings suggest intestinal permeability plays a critical role in regulating infections due to IBD.

Niu et al. (2025) studied this question.

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