What question did this study set out to answer?

To investigate the regional and cellular variability of intestinal paracellular permeability under physiological and stimulated conditions.

March 10, 2026FASEB BioAdvancesOpen Access

Mapping Intestinal Paracellular Perm Eability in Mice: Regional and Cellular Variability Under Physiological and Stimulated Conditions

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Authors

MMMathilde MiquelUniversité Toulouse III - Paul Sabatier KVKadirey VerwaerdeÉcole Nationale Vétérinaire de Toulouse AEAnissa Edir‐KibriInserm

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Implication

Ex vivo analysis examines how intestinal permeability varies in mice under normal, stressed, and lipid-rich conditions, suggesting significant implications for gut health.

Key Points

To investigate the regional and cellular variability of intestinal paracellular permeability under physiological and stimulated conditions.
Ex vivo incubation of intestinal tissue segments with fluorescent dyes at 0°C
Use of confocal microscopy to analyze permeability patterns
Comparison of healthy mice with those under chronic stress or on lipid diets
Healthy mice show limited FM staining, with increased permeability around specific cells like Goblet and enteroendocrine cells
Chronic stress causes increased permeability detected by FITC-dextran in vivo and ex vivo
Lipid-rich food administration boosts permeability around jejunal enterocytes

Cite This Study

Miquel et al. (2026) studied this question.

synapsesocial.com/papers/69af944f70916d39fea4b5a6 https://doi.org/10.1096/fba.2025-00325

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Implication

Ex vivo analysis examines how intestinal permeability varies in mice under normal, stressed, and lipid-rich conditions, suggesting significant implications for gut health.

Mapping Intestinal Paracellular Perm Eability in Mice: Regional and Cellular Variability Under Physiological and Stimulated Conditions

Discussion

Member takes

Implication

Key Points

Cite This Study

Mapping Intestinal Paracellular Perm Eability in Mice: Regional and Cellular Variability Under Physiological and Stimulated Conditions

Discussion

Member takes

Implication

Key Points

Cite This Study

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