Novel protocol synthesizes various alkyl and aryl 2-oxetanes using Giese addition to α-oxy radicals, suggesting advancements in synthetic methods.
Oxetanes have recently garnered large amounts of interest from synthetic chemists due to their unique structural and chemical properties. Despite substantial advances for the formation of 3,3-disubstituted oxetanes, its 2-functionalized counterparts remain a challenging synthetic motif. Furthermore, methods to form alkyl oxetanes remain underdeveloped. Herein, we dis-close a novel protocol for the synthesis of various alkyl and aryl 2-oxetanes leveraging a Giese addition to α-Oxy radicals, furnishing the desired products in up to 95% yield.
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Schindler et al. (2025) studied this question.
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