Visible-light-mediated synthesis of 2-oxetanes via Giese addition to α-oxy radicals

Matthew Liu; Elvis C. McFee; Corinna S. Schindler

doi:10.1039/d5sc07764h

January 1, 2026Chemical ScienceOpen Access

Visible-light-mediated synthesis of 2-oxetanes via Giese addition to α-oxy radicals

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Key Points

The aim is to develop an efficient method for synthesizing 2-oxetanes through a Giese addition process.
Developed a new protocol using visible light for the reaction.
Applied Giese addition to α-oxy radicals.
Synthesized a variety of alkyl and aryl 2-oxetanes.
Achieved product yields of up to 95%.
Demonstrated the effectiveness of visible light in this chemical synthesis.
Provided a versatile approach applicable to different substrates.

Implication

Novel protocol synthesizes 2-oxetanes using visible light in chemical reactions, indicating improved efficiency and yield.

Abstract

A novel protocol for the synthesis of various alkyl and aryl 2-oxetanes leveraging a Giese addition to α-oxy radicals is disclosed, furnishing the desired products in up to 95% yield.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/698979c8f0ec2af6756e7ab0 https://doi.org/10.1039/d5sc07764h

View Full Paper

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Visible-light-mediated synthesis of 2-oxetanes via Giese addition to α-oxy radicals

Key Points

Implication

Abstract

Discussion

Cite This Study

Visible-light-mediated synthesis of 2-oxetanes via Giese addition to α-oxy radicals

Key Points

Implication

Abstract

Discussion

Cite This Study

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