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circ₀049271 downregulation ameliorates lipopolysaccharide-induced human renal tubular endothelial cell apoptosis, inflammation and oxidative stress

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Experimental analysis shows alleviation of inflammation and apoptosis in HK-2 cells, suggesting circRNA modulation as a therapeutic strategy for AKI.

Downregulation of circ_0049271 attenuates LPS-induced apoptosis and oxidative stress in HK-2 cells.
Circ_0049271 was found to be upregulated in response to lipopolysaccharide treatment in HK-2 cells.
RNA interaction assays confirmed that circ_0049271 regulates HK-2 cell injury by targeting miR-331-3p.
This research highlights potential molecular targets for treating sepsis-associated AKI.

Ji et al. (2025) studied this question.

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Experimental analysis shows alleviation of inflammation and apoptosis in HK-2 cells, suggesting circRNA modulation as a therapeutic strategy for AKI.