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This is a In Vitro Study study.

September 10, 2025Open Access

Supplementary Figure 10 from Microbiota Shape Metabolic and Immune Determinants of CAR-T Therapy and Correlate with Outcomes in Myeloma

Key Points

Supplementary Figure S10 shows phenotypic details of CAR T-cells, specifically the role of succinate supplementation.
Analysis includes CD4+ naive and terminally differentiated T cells alongside measurements of exhaustion levels.
This investigation employs in vitro characterization of CAR T-cells using specified metabolic factors.
Insights may enhance understanding of CAR-T treatment outcomes in myeloma, supporting tailored therapies.

Abstract

upplementary Figure S10 provides a phenotypic characterization of in vitro expanded CAR T-cells that were supplemented with succinate. This includes an analysis of CD4+ naive and terminally differentiated effector T cells, as well as CD4+ T-cell exhaustion levels.

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