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This is a Observational study (also classified as: Network Toxicology, Animal Study).

September 10, 2025Frontiers in ToxicologyOpen Access

Exploring plasticisers-osteoporosis links and mechanisms: a cohort and network toxicology study

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Cohort analysis shows MEHP exposure correlates with osteoporosis risk, suggesting mechanisms involve apoptosis and key target molecules.

MEHP exposure is positively associated with osteoporosis risk, highlighting a significant health concern.
Logistic regression models revealed a strong correlation between MEHP levels and osteoporosis.
Network toxicology identified CTSD, VCP, and the apoptosis pathway as key mechanisms in osteoporosis.
Cellular experiments demonstrated that MEHP inhibits BMSC osteogenesis, emphasizing its detrimental effects.

Yang et al. (2025) studied this question.

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