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November 10, 2025International Journal of Molecular SciencesOpen Access

Network Toxicology and Molecular Docking Reveal the Toxicological Mechanisms of DEHP in Bone Diseases

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Authors

ZFZhonghao FanHDHaitao DuXZXinyi Zhou

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Overview

Network toxicology reveals DEHP disrupts bone homeostasis in osteoporosis and osteoarthritis, highlighting environmental health risks.

Key Points

  • This research investigates the toxicological mechanisms of DEHP on bone diseases.
  • Utilized network toxicology to connect DEHP with disease-related targets.
  • Conducted Venn analysis and protein–protein interaction network construction.
  • Performed Gene Ontology and KEGG enrichment analyses to identify signaling pathways.
  • Identified 109 overlapping targets of DEHP across osteoporosis and osteoarthritis.
  • Confirmed stable binding of DEHP to core targets via molecular docking and simulations.
  • Revealed disruption of osteoblast/osteoclast balance and inflammation in bone diseases.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/69253a16c0ce034ddc356e46https://doi.org/10.3390/ijms262210895
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