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September 10, 2025International Journal of Radiation Oncology*Biology*PhysicsOpen Access

Dosimetric Outcomes of SBRT to Ultra-central Lung Tumors: Lessons from the SUNSET trial

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Authors

RSRohan SalunkheDPDavid A. PalmaAWAndrew Warner

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Overview

Univariable logistic regression identified dosimetric predictors for adverse events in ultracentral lung tumors, suggesting dosage relationship impacts outcomes.

Key Points

  • Grade ≥2 adverse events occurred in 11 patients, indicating significant toxicity risks in ultracentral lung treatments.
  • The maximum dose (Dmax) reached an average of 69.3 Gy, showing the effects of SBRT dosage on different clinical outcomes.
  • Regression analysis revealed a hazard ratio of 2.86 for local control related to overlap volume of PTV with OARs.
  • Decreased overall survival was associated with reduced target coverage, highlighting the critical balance of dosimetric planning.

Cite This Study

Salunkhe et al. (2025) studied this question.

synapsesocial.com/papers/68c188509b7b07f3a06120aahttps://doi.org/10.1016/j.ijrobp.2025.08.052
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