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September 10, 2025

SP1-Induced LncRNA ZFAS1 Contributes to Cell Proliferation and Migration in Gastric Cancer through AKT/mTOR Signaling.

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Authors

YLYing LiUniversity of Science and Technology of ChinaYWYu WangJilin UniversityJGJun GaoAffiliated Hospital of Shaanxi University of Chinese Medicine

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Implication

Observational analysis shows ZFAS1 enhances cell proliferation and migration in gastric cancer, suggesting SP1 influence on AKT/mTOR signaling.

Key Points

  • Knockdown of ZFAS1 in gastric cancer cells significantly inhibits cell proliferation and migration.
  • SGC7901 cells exhibited elevated ZFAS1 expression linked to poor prognosis and enhanced AKT/mTOR signaling.
  • SP1 upregulates ZFAS1 transcription by binding to its promoter, triggering the activation of AKT/mTOR pathway components.
  • Targeting ZFAS1 presents potential therapeutic implications for more effective treatment strategies in gastric cancer.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c188659b7b07f3a0612cebhttps://doi.org/10.30498/ijb.2025.504573.4071
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