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August 16, 2026Biology DirectOpen Access

MZF1-AS1 promotes proliferation and invasion of lung adenocarcinoma cells by regulating the miR-27b-3p/KRAS axis

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Authors

CLCuiping LuFujian Medical UniversityQZQixiang ZhongFirst Hospital of China Medical UniversityHKHaifeng KanUniversity College London

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Implication

Cohort study demonstrates that elevated MZF1-AS1 drives cancer cell proliferation and invasion in lung adenocarcinoma, suggesting its utility as a prognostic biomarker and therapeutic target.

Key Points

  • To examine the prognostic role of the long non-coding RNA MZF1-AS1 in lung adenocarcinoma and determine how it regulates tumor progression via the miR-27b-3p/KRAS pathway.
  • Analyzed MZF1-AS1, miR-27b-3p, and KRAS expression in tumor and normal tissues from 136 patients with lung adenocarcinoma alongside a 5-year post-treatment follow-up.
  • Evaluated patient survival outcomes using Kaplan-Meier curves and Cox proportional hazards regression analyses.
  • Assessed cancer cell proliferation, migration, invasion, and direct RNA-binding targets using CCK-8, Transwell, and dual-luciferase reporter assays.
  • MZF1-AS1 expression was significantly upregulated in tumor tissues and served as an independent risk factor for poor 5-year survival in lung adenocarcinoma.
  • Knockdown of MZF1-AS1 significantly suppressed adenocarcinoma cell proliferation, migration, and invasive capability in vitro.
  • MZF1-AS1 functioned as a competing endogenous RNA that bound to and inhibited miR-27b-3p, thereby releasing the repression on KRAS and driving cancer progression.

Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a817a01f2fb91fc834ad7c3https://doi.org/10.1186/s13062-026-00936-8
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