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July 27, 2026HereditasOpen Access

Targeting RASL12 by miR-6791-5p fuels malignant progression in lung adenocarcinoma

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Authors

LZLu ZhangQuzhou City People's HospitalZPZhonghao PangJiangsu UniversityHZHaitao ZhangWannan Medical College

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Implication

Randomized trial investigates miR-6791-5p's role in promoting malignant traits in lung adenocarcinoma, indicating therapeutic potential.

Key Points

  • This research aims to clarify the involvement of miR-6791-5p and its target RASL12 in the progression of lung adenocarcinoma (LUAD).
  • Analyzed expression profiles in 203 LUAD patients and cell lines, alongside public databases.
  • Conducted CCK-8 and Transwell assays to evaluate biological functions and RASL12 knockdown and rescue assays for functional validation.
  • Performed dual-luciferase assays for target interaction validation and Gene Set Enrichment Analysis (GSEA) to link downstream pathways.
  • miR-6791-5p was upregulated in LUAD (p < 0.001) and independently predicted poorer overall survival (HR = 2.411, p = 0.003).
  • High levels of miR-6791-5p promoted LUAD cell proliferation, migration, and invasion.
  • Knockdown of RASL12 enhanced tumor aggressiveness, while co-knockdown with miR-6791-5p inhibition partially reversed tumor growth effects.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a6700bd40bca442e0d4ac7chttps://doi.org/10.1186/s41065-026-00697-4
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