Association of Scrum Uric Acid Levels in Type-2 Diabetic Patients

Diabetes Mellitus is a chronic disorder that is associated with cardiovascular complications, renal complications and various types of microangiopathies including metabolic syndrome. Hyperuricemia is associated with type 2 diabetes, which is a metabolic disorder of multiple etiologies resulting from defects in insulin action. The present study was carried out to look for any association between uric acid and Type II Diabetes Mellitus. Elevated serum uric acid (SUA) levels have been linked to several metabolic disorders, including diabetes. However, the relationship between SUA levels is underexplored. This study aimed to assess the association between SUA levels in Type-2 Diabetic patients. Materials And Methods: This is a case-controlled study, with 50 cases as Type 2 diabetic patients and 50 healthy individuals as controls. Sociodemographic and clinical data, including BMI, waist-hip ratio (WHR), blood pressure and diabetes duration, were collected. Serum uric acid levels were measured using the uricase method. Data were analyzed with SPSS version 21, using independent t-tests and chisquare tests for comparisons between groups. Results: s significantly higher in the diabetic group (5.88 ± 1.04 mg/dl) compared to controls (4.13 ± 0.85 mg/dl). A positive correlation was found between SUA levels and BMI (r = 0.45) and WHR (r = 0.38). Diabetic patients with hypertension had significantly higher SUA levels (6.60 ± 1.10 mg/dl) than non-hypertensive patients (4.79 ± 1.18 mg/dl, P < 0.05). SUA levels also increased with diabetes duration, with the highest levels in patients with diabetes for 9-12 years (6.47 ± 1.07 mg/dl). Conclusion: This study found that serum uric acid levels were significantly higher in T2DM patients and positively correlated with BMI, WHR, and hypertension. This study documents that hyperuricemia is associated with type 2 diabetes mellitus. Regular monitoring of SUA can be useful in managing T2DM patients to prevent complications.