Hematologic Variations in Children With Down Syndrome

Hematologic abnormalities in children with Down Syndrome (DS) have previously been described, but with inconsistent conclusions. A retrospective single-institution cohort study was conducted to evaluate complete blood count (CBC) ranges in children with DS. Mean values for CBC results are presented by age and sex, as a clinical resource for the evaluation of DS children. In comparison to reference values, children with DS had higher mean corpuscular volume (MCV), lower absolute lymphocyte count, and a trend toward higher hemoglobin (Hgb) values. The presence of these findings across the cohort suggests that these are benign hematologic variations in DS.