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September 10, 2025Clinical Pharmacology & TherapeuticsOpen Access

Recruiting and Consenting Decentralized Clinical Trial Participants—Learnings from the Trials@Home RADIAL Proof‐of‐Concept Trial

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Authors

BLBart LagerwaardLRLinda RutgrinkDWDanny van Weelij

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Overview

Open-label trial optimized recruitment strategies and eConsent processes in participants with type 2 diabetes, suggesting improvements are needed.

Key Points

  • Decentralized clinical trials enabled more accessible participation for patients, yet recruitment remains challenging.
  • Online recruitment campaigns created high visibility but generated only minimal enrolment, particularly in the initial consent phase.
  • Outreach through research databases proved significantly more effective, contributing to most enrollments in the RADIAL trial.
  • The introduction of eConsent required meticulous resource investment, highlighting the need for streamlined processes in diverse regulatory environments.

Cite This Study

Lagerwaard et al. (2025) studied this question.

synapsesocial.com/papers/68c189e09b7b07f3a06138e9https://doi.org/10.1002/cpt.70042
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  1. 1Selecting and Preparing Clinical Sites for the Successful Conduct of Decentralized Clinical Trial Activities–Findings From the Trials@Home <scp>RADIAL</scp> Proof‐of‐Concept Trial2025
  2. 2The Supply of Investigational Medicinal Product and Management of Study Materials for Decentralized Participants—Insights from the Trials@Home <scp>RADIAL</scp> Proof‐of‐Concept Trial2025 · 1 citations
  3. 3Bringing Trial Activities to Participants—The Trials@Home <scp>RADIAL</scp> Proof‐of‐Concept Trial Investigating Decentralization of Trials2025 · 8 citations
  4. 4Operationalizing Decentralized Clinical Trials: Technology Insights from the Trials@Home <scp>RADIAL</scp> Proof‐of‐Concept Trial2025 · 8 citations
  5. 5Regulatory Interactions and Learnings—<scp>RADIAL</scp> the Trials@Home Proof‐of‐Concept Trial on Decentralization2025