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September 10, 2025BMJ Case Reports

Severe, prolonged primary hypothyroidism causing ovarian hyperstimulation: an adult presentation (Van Wyk–Grumbach syndrome)

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Authors

SCShyam Chand ChaudharyKing George's Medical University SSShambhavi SinhaKing George's Medical University TPTarun PalKing George's Medical University

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Implication

Case report describes adult occurrence of van wyk-grumbach syndrome with severe anaemia, suggesting early identification is vital for better outcomes.

Key Points

Successful conception followed treatment emphasizes the significance of timely thyroid hormone replacement.
Laboratory tests revealed elevated thyroid-stimulating hormones and low luteinising hormones, indicating severe hypothyroidism.
Imaging showed enlarged multicystic ovaries and a hypoplastic thyroid, supporting the diagnosis of van wyk-grumbach syndrome.
Identifying van wyk-grumbach syndrome early can reverse hormonal disturbances, preventing surgical interventions.

Cite This Study

Chaudhary et al. (2025) studied this question.

synapsesocial.com/papers/68c189e79b7b07f3a0613c56 https://doi.org/10.1136/bcr-2024-264391

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Implication

Case report describes adult occurrence of van wyk-grumbach syndrome with severe anaemia, suggesting early identification is vital for better outcomes.

Severe, prolonged primary hypothyroidism causing ovarian hyperstimulation: an adult presentation (Van Wyk–Grumbach syndrome)

Discussion

Member takes

Implication

Key Points

Cite This Study

Severe, prolonged primary hypothyroidism causing ovarian hyperstimulation: an adult presentation (Van Wyk–Grumbach syndrome)

Discussion

Member takes

Implication

Key Points

Cite This Study

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