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September 10, 2025Organic Letters

Exploring the Radical Addition to Sydnones: A Gateway to Perfluoroalkyl-Substituted Pyrazoles

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Radical addition facilitates functionalization of sydnones with perfluoroalkyl groups, suggesting new pathways for pyrazole synthesis.

The successful radical addition enables the functionalization of sydnones, yielding novel perfluoroalkylated pyrazole derivatives.
Fluorinated sydnones underwent energy-transfer-mediated cycloaddition, achieving complete regiocontrol of the products.
This approach highlights a new strategy in synthesizing medicinally relevant compounds, enhancing potential drug development paths.
Radical addition represents a significant advancement in mesoionic heterocycle chemistry, paving the way for innovative compound synthesis.

Rubanov et al. (2025) studied this question.

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