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September 10, 2025Methods and ProtocolsOpen Access

Analysis of the Effect of the Tablet Matrix on the Polymorphism of Ibuprofen, Naproxen, and Naproxen Sodium in Commercially Available Pharmaceutical Formulations

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Authors

ELEdyta LeykMŚMarcin ŚrodaGMGracjan Maślanka

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Overview

Observational analysis shows excipients influence the polymorphism of active ingredients, suggesting effects on drug bioavailability.

Key Points

  • The analysis reveals excipients significantly affect the polymorphism of ibuprofen and naproxen in commercial formulations.
  • Excipients were shown to modify melting behavior, evidenced by DSC results indicating broadened and shifted melting peaks.
  • Fourier transform infrared spectroscopy and Raman spectroscopy confirmed the presence of active substances, despite polymorphic changes.
  • X-ray diffraction analysis excluded chemical interactions between excipients and active ingredients, highlighting their role in altering crystalline form.

Cite This Study

Leyk et al. (2025) studied this question.

synapsesocial.com/papers/68c18bf99b7b07f3a0614141https://doi.org/10.3390/mps8050099
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Also Consider

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  1. 1Preparation and evaluation of naproxen ternary solid dispersion using genetically modified cassava starch and hydroxypropyl methyl cellulose2024
  2. 2Effect of Mixing Technology on Homogeneity and Quality of Sodium Naproxen Tablets: Technological and Analytical Evaluation Using HPLC Method2025
  3. 3Polymorphism in Antidiabetic Drugs: Analytical Characterization and its Impact on Pharmaceutical Performance2026
  4. 4Impact of Methods of Preparation on Mechanical Properties, Dissolution Behavior, and Tableting Characteristics of Ibuprofen-Loaded Amorphous Solid Dispersions2024 · 3 citations
  5. 5Synthesis, Characterization, and Stability Optimization of Ibuprofen Cocrystals eEploying Various Hydrophilic Polymers2024 · 4 citations