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September 10, 2025Cardiovascular ResearchOpen Access

In PLN-R14del mice, SR structure restoration, rather than calcium cycling, is the dominant effector of PLN-ASO treatment

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Authors

LSLiu SunTETim R. EijgenraamCACarl Amilon

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Overview

Observational analysis reveals PLN-ASO treatment improves cardiac function in PLN-R14del mice, highlighting SR structure restoration as the key mechanism.

Key Points

  • PLN-ASO treatment enhanced survival and cardiac function in PLN-R14del mice, with reduced abnormal PLN-SR clustering.
  • ASO therapy showed a dose-dependent relationship with improved cardiac outcomes, particularly diminishing myocardial fibrosis.
  • Investigations on cardiomyocytes highlighted limited effects of ASO on calcium dynamics due to pre-existing enhancements in R14Δ/Δ mice.
  • Restoration of SR organization was confirmed as the predominant therapeutic action of PLN-ASO in combating cardiomyopathy.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68c18c019b7b07f3a061454bhttps://doi.org/10.1093/cvr/cvaf156
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