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Observational analysis discovered ctDNA in plasma up to 3 years before diagnosis, highlighting the utility of multimodal detection methods.
Summary: Wang and colleagues showed that ctDNA can be detected in plasma up to 3 years prior to clinical diagnosis. The study highlights the need for ultrasensitive and multimodal approaches that integrate the detection of mutations and copy-number changes with advanced computational platforms to deliver effective early-detection strategies. See related article by Wang et al., p. 1794
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Crisafulli et al. (2025) studied this question.
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