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September 10, 2025British journal of surgeryOpen Access

The NEON (Nerve rEpair Or Not) trial: a randomized controlled trial of microsurgical repair versus nerve alignment for digital nerve injury

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Randomized controlled trial found no significant differences in outcomes for digital nerve injury, suggesting nerve alignment may suffice.

The primary outcome showed no significant differences in I-HaND scores between repair and alignment methods.
Results demonstrated nearly identical outcomes in neurosensory recovery and quality of life metrics at 12 months.
This multicentre randomized controlled trial involved 122 adults who underwent surgical evaluation and randomization.
The findings challenge the necessity of microsurgical repair for isolated digital nerve injury, guiding clinical policy.

Wormald et al. (2025) studied this question.

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Randomized controlled trial found no significant differences in outcomes for digital nerve injury, suggesting nerve alignment may suffice.