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This study explores collection efficiency of the new generation medical impactor, indicating factors like inlet flow rate and filter membranes.
The new generation medical impactor (NGI) is used to evaluate the aerodynamic particle size and particle size distribution of the particles after atomization of pharmaceutical preparations, which is of great significance for optimizing the inhalation adhesion site and therapeutic effect of pharmaceutical particles, and has been widely used in the field of inhalation drug preparations detection, but there is a lack of corresponding product standards and detection means. In this study, the evaluation method of physical collection efficiency based on aerodynamic particle size spectrometer was established by reforming the NGI, and the key performance evaluation of this new type of equipment was realized. The results showed that due to the influence of the detection limit of aerodynamic method (> 0.5μm), a method that can measure the number of smaller particles can be further developed to evaluate the collection efficiency of high-level sampling samples, so as to further improve the evaluation method. At the same time, the influence of inlet flow rate, filter membrane, and the influence of glycerin coating on the physical collection efficiency were explored, which has important reference significance for NGI equipment selection and instrument quality improvement.
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Tian et al. (2025) studied this question.
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