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September 10, 2025Lupus

Efficacy and safety of Belimumab, Rituximab and Voclosporin in the treatment of lupus nephritis based on registered clinical trials: A systematic review and network meta-analysis

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Authors

FLFeigao LiXLXizhe LiuXZXinhui Zhang

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Overview

Systematic review and network meta-analysis reveals Voclosporin is more effective than Rituximab, indicating safety concerns.

Key Points

  • Voclosporin and Belimumab showed significant clinical efficacy for lupus nephritis, with Voclosporin outperforming Rituximab.
  • In complete renal remission rates, Voclosporin demonstrated a notable improvement compared to placebo and Rituximab.
  • Safety analysis revealed that High-Voclosporin posed greater risks than placebo, but serious adverse events were similar across treatments.
  • This review synthesizes findings from five randomized controlled trials involving over 1200 subjects treated for lupus nephritis.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c18f399b7b07f3a0615b02https://doi.org/10.1177/09612033251378388
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