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May 6, 2026Glomerular DiseasesOpen Access

Case series of the combination of voclosporin and belimumab treatment of lupus nephritis

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Authors

HTHoma TimlinAKAbbal KoiralaDGDuvuru Geetha

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Overview

Case series shows improved kidney function and lower proteinuria in lupus nephritis, suggesting that voclosporin and belimumab are effective treatments.

Key Points

  • This research aims to evaluate the effectiveness and safety of combining voclosporin and belimumab in lupus nephritis patients.
  • Retrospective case series of 16 female lupus nephritis patients
  • Evaluated combination therapy of voclosporin and belimumab
  • Analyzed longitudinal data for key biomarkers
  • Marked reduction in proteinuria from 2.175 g/g to 0.082 g/g
  • Increased complement levels C3 from 65.0 to 109.5 and C4 from 6.5 to 20.5
  • 62.5% of patients tapered corticosteroids to ≤5 mg/day or discontinued them

Cite This Study

Timlin et al. (2026) studied this question.

synapsesocial.com/papers/69fa8ef304f884e66b531649https://doi.org/10.1159/000552239
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of Belimumab, Rituximab and Voclosporin in the treatment of lupus nephritis based on registered clinical trials: A systematic review and network meta-analysis2025
  2. 2Rapid Reduction in Proteinuria With the Initiation of Voclosporin in Lupus Nephritis: A Single-Center Experience2026
  3. 3P159 New kids on the block - real-world experience of using belimumab, obinutuzumab and voclosporin in systemic lupus erythematosus. A retrospective cohort study in University College London Hospital2026
  4. 4Early antiproteinuric effect of voclosporin in patients with lupus nephritis in a real-life setting: preliminary results from the VoRLiSS ( <u>Vo</u> closporin in <u>R</u> eal <u>Li</u> fe <u>S</u> etting <u>S</u> tudy) experience2025 · 1 citations
  5. 5Voclosporin Treatment of Proliferative Lupus Nephritis in Childhood, a Case Report2026