Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 9, 2025Lara D. VeekenOpen Access

Early antiproteinuric effect of voclosporin in patients with lupus nephritis in a real-life setting: preliminary results from the VoRLiSS ( Vo closporin in R eal Li fe S etting S tudy) experience

View Full Paper
Ask AI
Bookmark
Share

Authors

LILuca IaccarinoAGAda Di GregorioMCMarta Calatroni

Discussion

Loading...

Member takes

Overview

Observational study demonstrates early renal response in lupus nephritis, suggesting voclosporin's effectiveness.

Key Points

  • To evaluate the efficacy of voclosporin in managing lupus nephritis among patients in a clinical practice setting.
  • Retrospective, observational, multicentre study in Italy
  • Patients with biopsy-proven lupus nephritis enrolled between November 2023 and April 2025
  • Patients received oral voclosporin and MMF with a glucocorticoid regimen as per guidelines
  • 31.5% achieved complete or partial renal response at 6 weeks, increasing to 91.6% at 48 weeks
  • Significant decrease in 24-h proteinuria observed at 6 weeks (p=0.006) and all time points thereafter
  • Mild decrease in eGFR noted at 6 and 24 weeks, but not at 48 weeks

Cite This Study

Iaccarino et al. (2025) studied this question.

synapsesocial.com/papers/69401efa2d562116f28f99cahttps://doi.org/10.1093/rheumatology/keaf654
View Full Paper
Ask AI
Bookmark
Share