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May 31, 2026Kidney International Case ReportsOpen Access

Voclosporin Treatment of Proliferative Lupus Nephritis in Childhood, a Case Report

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Authors

ECEllen CodySMSiri McCordDFDanielle Fair

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Overview

Case report demonstrates voclosporin's effectiveness in reducing proteinuria in pediatric lupus nephritis, suggesting a viable treatment option.

Key Points

  • The aim is to assess the effectiveness and safety of voclosporin in treating proliferative lupus nephritis in children.
  • Presented two cases of pediatric patients with systemic lupus erythematosus and biopsy-confirmed lupus nephritis.
  • Monitored proteinuria levels and treatment responses following the introduction of voclosporin.
  • Treatment included a regimen of steroids, mycophenolate mofetil, and either belimumab or voclosporin.
  • In the first patient, proteinuria improved to near normal within 2 months post-treatment with voclosporin.
  • Repeat biopsy after 10 months showed complete resolution of active disease with no adverse effects from the calcineurin inhibitor.
  • The second patient experienced resolution of proteinuria one month after starting voclosporin, allowing for safe steroid tapering.

Cite This Study

Cody et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd0155783ba022b6fbf70https://doi.org/10.1016/j.kintcr.2026.100037
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