This study utilizes ligand engineering to enhance detection sensitivity and light absorption in chlorantraniliprole assays, highlighting advancements in food contaminant screening.
The photothermal lateral flow immunoassay (LFIA) has garnered considerable attention, owing to its suitability for on-site quantitative detection. Furthermore, it has distinct advantages in further constructing sensitive detection methods for low-concentration targets. In this study, we employed a ligand engineering strategy to synthesize Fe3+-chelated quinone nanoparticles (FQNPs). Quinones with different structures, namely, naphthazarin, quinizarine, purpurin, and tetrahydroxyanthraquinone (THAQ), served as ligands to fabricate a series of FQNPs. Among them, FQNPs based on tetrahydroxyanthraquinone (FQNPs-T) exhibited exceptional light absorption ability (molar extinction coefficient = 12.71 × 1010 M-1 cm-1) and photothermal conversion efficiency (η = 60.32%). Subsequently, a photothermal LFIA based on FQNPs-T (FQNPs-LFIA) was developed for the detection of chlorantraniliprole (CHL) in apple and chili. The FQNPs-LFIA enables the highly sensitive detection of CHL within 25 min with a limit of detection (LOD) of 0.021 ng mL-1, which was 8.77-fold lower than that of conventional gold nanoparticle-based LFIA (0.193 ng mL-1). The average recovery rates of FQNPs-LFIA were 84.29-113.58%, with coefficients of variation of 4.20-14.84%. Overall, this study demonstrates the potential of FQNPs-LFIA for the sensitive and accurate detection of CHL, and it paves the way for the rapid screening of other food contaminants.
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Chen et al. (2025) studied this question.
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