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September 10, 2025Journal of applied science and environmental managementOpen Access

Effects of Insulin, Metformin, and Canagliflozin on Blood Glucose and Liver Histology in Streptozotocin-Induced Type 2 Diabetic Pregnant Wistar Rats

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RARobert AkpataUniversité de Bordeaux IOI. J. Obiefule MIM.O.O. Iyamu

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Implication

This study investigates how insulin and newer drugs affect blood glucose and liver histology in diabetic rats, highlighting potential benefits of canagliflozin.

Key Points

Canagliflozin effectively reduced blood glucose levels and improved liver architecture compared to insulin and metformin.
Liver histology analysis revealed near-normal conditions in canagliflozin-treated rats, with significant damage observed in untreated diabetic rats.
Blood glucose and body weight were closely monitored across different treatment groups to assess overall health outcomes.
This research supports the potential of canagliflozin in managing liver-related diabetes complications based on its superior effects.

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Akpata et al. (2025) studied this question.

synapsesocial.com/papers/68c192579b7b07f3a0616c62 https://doi.org/10.4314/jasem.v29i8.15

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Implication

This study investigates how insulin and newer drugs affect blood glucose and liver histology in diabetic rats, highlighting potential benefits of canagliflozin.

Effects of Insulin, Metformin, and Canagliflozin on Blood Glucose and Liver Histology in Streptozotocin-Induced Type 2 Diabetic Pregnant Wistar Rats

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Key Points

Cite This Study

Effects of Insulin, Metformin, and Canagliflozin on Blood Glucose and Liver Histology in Streptozotocin-Induced Type 2 Diabetic Pregnant Wistar Rats

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Cite This Study

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