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September 12, 2025Sokoto Journal of Medical Laboratory ScienceOpen Access

Impact of diabetes mellitus on female reproductive physiology: Role of oxidative stress and metabolic dysregulation

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Authors

RARobert AkpataUniversité de Bordeaux MIM.O.O. Iyamu IOI. J. Obiefule

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Implication

Analysis reveals varying effects of insulin, metformin, and canagliflozin on ovarian morphology in diabetic rats, suggesting a role for metabolic dysregulation and oxidative stress.

Key Points

Canagliflozin treatment showed superior efficacy in restoring ovarian morphology compared to insulin and metformin.
Histological examination indicated significant reductions in blood glucose levels for all treated groups, with canagliflozin demonstrating the greatest improvement.
Diabetes affected reproductive physiology, with folliculogenesis and steroidogenesis impaired, leading to fertility issues.
Treatment with canagliflozin resulted in well-formed follicles and normal stroma, indicating its potential advantage during diabetic pregnancy.

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Akpata et al. (2025) studied this question.

synapsesocial.com/papers/68d44b2a31b076d99fa54346 https://doi.org/10.4314/sokjmls.v10i2.18

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Implication

Analysis reveals varying effects of insulin, metformin, and canagliflozin on ovarian morphology in diabetic rats, suggesting a role for metabolic dysregulation and oxidative stress.

Impact of diabetes mellitus on female reproductive physiology: Role of oxidative stress and metabolic dysregulation

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of diabetes mellitus on female reproductive physiology: Role of oxidative stress and metabolic dysregulation

Discussion

Member takes

Implication

Key Points

Cite This Study

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