Randomized trial investigates ovarian function improvement in diabetic rats using Pioglitazone and Cynara scolymus extract, suggesting a new treatment for reproductive health issues.
Key Points
This research aims to explore the combined effects of Pioglitazone and Cynara scolymus extract on ovarian dysfunction in diabetic rats.
35 female rats were assigned to five groups: control, diabetic control, Pioglitazone, Cynara scolymus extract, and combined treatment.
Treatment was administered orally for 30 consecutive days.
Histopathological and stereological analyses evaluated follicular development and oxidative stress markers.
Combined treatment (DM + Piog + Cynara) significantly increased preantral, antral, and Graafian follicles and enhanced corpus luteum volume.
Compared to the diabetic group, atretic follicles decreased and fasting blood glucose levels were notably reduced.
Combination therapy improved oxidative stress markers by enhancing Bcl-2 expression and reducing Caspase-9 activity.