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September 10, 2025

Analysis of the heterogeneity of the BCR H-CDR3 repertoire in peripheral blood B cells of adult women with increasing age in Central China

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Analysis shows aging affects BCR H-CDR3 dynamics in B cells, highlighting changes in IGHV gene usage.

The study revealed that CDR3 amino acid length is longer in middle-aged adults compared to young and elderly groups.
An increase in the number of shared amino acid sequences in BCR indicates cumulative antigen exposure with age.
Significant differences in IGHV gene usage suggest age influences immune system genetics.
Despite no notable differences in clonal diversity, the elderly exhibited a concentrated clonal frequency distribution.

Ma et al. (2025) studied this question.

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