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This research aims to examine age-related changes in the B-cell repertoire and their implications for immune function.

November 1, 2025The Journal of ImmunologyOpen Access

Age-related BCR heavy chain repertoire changes in young and older adults tracked for a decade 9178

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Longitudinal study shows decline in naive B cells with age in healthy individuals, highlighting immune changes.

This research aims to examine age-related changes in the B-cell repertoire and their implications for immune function.
Longitudinal study of 74 healthy individuals with annual blood sampling over a decade.
Characterization of immunoglobulin heavy chain libraries from peripheral blood B cells via high throughput DNA sequencing.
Analysis of naive and non-naive B-cell repertoires and V-gene usage patterns.
Observed a non-linear decline in the percentage of naive B cells in older adults, particularly after age 60.
Younger individuals exhibited more public naive B cell clones and similar V gene usage compared to the elderly.
Divergence in V-gene usage patterns in non-naive B cell repertoires, notably in IgG and IgM, linked to expanded B cell clones.

Skatova et al. (2025) studied this question.

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