Figure 2 from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression

Prognostic impact of GALNT7 and the association between GALNT7 and PD-L1 (CD274) in colorectal cancer, stratified by MSI status. A–F, Kaplan–Meier curves for OS in TCGA cohort (A and D), PFS in the AC-ICAM cohort (B and E), and RFS in the GSE39582 cohort (C and F), analyzed separately for MSI (A–C) and MSS (D–F) colorectal cancers according to the expression of GALNT7. Patients were dichotomized as high or low based on the median expression of GALNT7 in each analysis. Log-rank P values, Cox HRs, and 95% CIs are indicated. G–I, Heatmaps depicting MSI status, GALNT7 expression, CMS, BRAF mutations, TMB, immune infiltration estimated using the ESTIMATE, and the expression of immune checkpoint genes in TCGA (G), AC-ICAM (H), and GSE39582 (I). J–L, Correlations between CD274 and GALNT7 mRNA expression according to MSI status in TCGA (J), AC-ICAM (K), and GSE39582 (L). M, Correlations between CD274 and GALNT7 protein expression according to MSI status in CPTAC. Pearson correlation coefficients are indicated. ***, P < 0.001; **, P < 0.01; *, P < 0.05; n.s. P > 0.05.