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September 10, 2025BiomedicinesOpen Access

Perioperative Oral Immunonutrient Regulation of Intestinal Barrier and Gut Microbiota in Patients with Gastric Cancer, a Randomized Controlled Clinical Trial

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Authors

ZZZicheng ZhengGLGuanmo LiuYWYihua Wang

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Overview

Randomized controlled trial shows immunonutrients enhance intestinal barrier and gut microbiota in gastric cancer patients, indicating potential therapeutic benefits.

Key Points

  • Immunonutrients may attenuate surgery-induced intestinal barrier damage in gastric cancer patients, enhancing microbiota diversity.
  • The immunonutrients group showed significantly lower postoperative diamine oxidase and endotoxin levels, indicating improved intestinal barrier function.
  • Patients receiving immunonutrients exhibited changes in gut microbiota, with an increase in beneficial genera like Akkermansia and Bifidobacterium longum.
  • Functional pathway analysis suggested that immunonutrients play a role in enriching beneficial taxa and suppressing pathogenic bacteria.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/68c192579b7b07f3a0616e27https://doi.org/10.3390/biomedicines13092163
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The impact of enteral immunonutrition on gut microbiota in colorectal cancer and gastric cancer patients in the preoperative period—preliminary results of randomized clinical trial2025 · 7 citations
  2. 2Impact of Immunonutrition on Nutritional Status in Patients Undergoing Colorectal Cancer Surgery: A Randomized Controlled Clinical Trial2024 · 8 citations
  3. 3Perioperative Immunonutrition in Gastrointestinal Oncology: A Comprehensive Umbrella Review and Meta-Analysis on Behalf of TROGSS—The Robotic Global Surgical Society2025 · 19 citations
  4. 4Effect of preoperative immunonutrition on postoperative short-term clinical outcomes in patients with gastric cancer cachexia: a prospective randomized controlled trial2024 · 40 citations
  5. 5Effects of Immunonutrition on Intestinal Microecology in Patients With Gastrointestinal Cancers: Mechanisms and Clinical Applications2026