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September 10, 2025PathogensOpen Access

Differential Gene Expression and Protein–Protein Interaction Networks in Bovine Leukemia Virus Infected Cattle: An RNA-Seq Study

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Authors

AMAna Silvia González MéndezMinistry of Agriculture and ForestryMAMohammad Mehdi AkbarinIslamic Azad University, MashhadFCFernando Cerón-TéllezMinistry of Agriculture and Forestry

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Overview

RNA-seq analysis reveals differential gene expression and immune responses in cattle, suggesting pathways to lymphoma development.

Key Points

  • The analysis found that transcription activation factors were upregulated in asymptomatic carriers of bovine leukemia virus compared to healthy controls.
  • Compared to healthy controls, anti-inflammatory cytokines increased in cattle with persistent lymphocytosis, indicating altered immune responses.
  • RNA-seq was employed to analyze gene expression and protein–protein interaction networks across different cattle groups affected by bovine leukemia virus.
  • The findings suggest that certain protein interactions may play a critical role in the oncogenesis process related to severe BLV infections.

Cite This Study

Méndez et al. (2025) studied this question.

synapsesocial.com/papers/68c192579b7b07f3a0616f24https://doi.org/10.3390/pathogens14090887
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