Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 13, 2026VirusesOpen Access

Detection of Bovine Leukemia Virus in Bone Marrow of Patients with B-Cell Precursor Acute Lymphoblastic Leukemia: A Case–Control Study

View Full Paper
Ask AI
Bookmark
Share

Authors

KNKerlimber Núñez-GutiérrezJFJosé G. Fuentes-MontoyaLELeonardo Enciso

Discussion

Loading...

Member takes

Overview

Case-control study finds bovine leukemia virus in bone marrow of B-ALL patients, suggesting potential connections to hematological diseases.

Key Points

  • The study aims to explore the presence of bovine leukemia virus (BLV) in patients with B-cell precursor acute lymphoblastic leukemia (B-ALL).
  • Compared 11 B-ALL cases with 47 healthy controls
  • Assessed anti-gp51 antibodies and BLV proviral DNA in bone marrow and blood samples
  • Used quantitative PCR to detect proviral DNA targeting the pol gene
  • Conducted conventional and nested PCR for viral genes
  • Performed Bayesian Chow–Liu network analyses to identify dependencies among viral genes
  • Seropositivity for anti-gp51 observed only in B-ALL group (18.2%; 2/11)
  • 74.1% of samples showed proviral DNA, with no significant differences between cases and controls
  • Amplification of the tax gene significantly associated with B-ALL, while gag and env were not
  • Detected BLV strains clustered with human and bovine sequences from Colombia, all within genotype 1

Cite This Study

Núñez-Gutiérrez et al. (2026) studied this question.

synapsesocial.com/papers/69b3aba202a1e69014ccc9eahttps://doi.org/10.3390/v18030342
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Gene Expression and Protein–Protein Interaction Networks in Bovine Leukemia Virus Infected Cattle: An RNA-Seq Study2025 · 4 citations
  2. 2Bovine Leukemia Virus Prevalence in Women with Breast Cancer and Premalignant Breast Lesions2026
  3. 3The Prevalence and Molecular Characterization of Bovine Leukemia Virus among Dairy Cattle in Henan Province, China2024 · 5 citations
  4. 4Bovine Leukemia Virus molecular detection and associated factors among dairy herd workers in Antioquia, Colombia2024 · 1 citations
  5. 5High-throughput detection of bovine leukocyte antigen (BoLA)-DRB3 alleles associated with resistance to bovine leukemia virus using a rapid allele-specific PCR assay2025