Anti-Stress Properties of Mojeaga Herbal Remedy® using an Unpredictable Mild Stress Animal Model

Mojeaga herbal remedy® (Mojeaga) is a mixture of the herbs Alchornea laxiflora, Pennisetum purpureum, and Sorghum bicolor. It is used to manage anaemia, boost the immune system, and protect cells from damage. This study evaluated the antistress property of Mojeaga on mice. Twenty-four mice were randomly allotted to six groups: Group 1 received 10 mL/kg of distilled water without any stress. Groups 2–4 received Mojeaga extract (5, 10, and 20 mg/kg), group 5 received fluoxetine 20 mg/kg, and group 6 received distilled water orally for 7 days. With the exception of group 1 mice, the mice in groups 2-4 were subjected to various stressors for 7 days. In the forced swimming and tail suspension tests, the Mojeaga extract at doses of 10 and 20 mg/kg, along with fluoxetine at 20 mg/kg, reduced the time of immobility compared to the stress control group (p < 0.05). The level of cortisol was reduced by Mojeaga extract at 5, 10, and 20 mg/kg and fluoxetine (20 mg/kg) when compared with stress control (p < 0.01). The Mojeaga extract at doses of 10 and 20 mg/kg increased the activities of superoxide dismutase and catalase, and at doses of 5 and 10 mg/kg, it lowered the level of malondialdehyde compared to the stress control group. The extract had no effect on the activity of glutathione peroxidase and glutathione reductase. Mojeaga possesses antistress activity.