Chronotropic incompetence during exercise or pharmacological stress is associated with reduced survival in patients with chronic coronary syndromes
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Discussion
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Implication
Observational study finds chronotropic incompetence predicts 10-year mortality in chronic coronary syndromes, suggesting significant prognostic value.
Key Points
- Chronotropic incompetence significantly increases 10-year mortality in patients with chronic coronary syndromes.
- Overall, 39% of patients with chronotropic incompetence died in 10 years compared to 21% without it.
- The study followed 13,445 patients over a median of 3.4 years, assessing the risk stratification value of chronotropic incompetence.
- Cox multivariable analysis indicated that chronotropic incompetence was an independent predictor of mortality alongside other factors.
Cite This Study
Cortigiani et al. (2025) studied this question.