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December 1, 2010Acta cardiologica. Supplementum

The presence of severe injuries in the right coronary artery was independently associated with chronotropic incompetence (adjusted OR = 3.57, 95% CI: 1.86-6.87).

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Why the study?

Is chronotropic incompetence associated with specific wall motion abnormalities and coronary arterial lesions in patients with ischaemia?

Population

610 patients with ischaemia who underwent exercise echocardiography, mean age 58.4 +/- 11 years, 275 men.

Comparison

Chronotropic incompetence vs Chronotropic competence

Design

Cross-sectional

Authors

FAFernando D Anjos-AndradeASAntônio Carlos Sobral SousaJBJosé Augusto Soares Barreto-Filho

Discussion

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Overview

RCA lesions associate with chronotropic incompetence in ischemia; hypothesis-generating and should not yet change practice or testing interpretation.

Structured PICO

Is chronotropic incompetence associated with specific wall motion abnormalities and coronary arterial lesions in patients with ischaemia?

P
Population
610 patients with ischaemia who underwent exercise echocardiography, mean age 58.4 +/- 11 years, 275 men.
I
Intervention
Chronotropic incompetence (failure to reach 85% of maximum age-predicted heart rate during treadmill testing)
C
Comparator
Chronotropic competence (achieving 85% of maximum age-predicted heart rate)
O
Outcome
Wall motion abnormalities of the left ventricle and location of coronary arterial lesionssurrogate

Chronotropic incompetence in patients with ischaemia is associated with worse ventricular dysfunction during peak exercise and critical right coronary artery lesions.

Cite This Study

Anjos-Andrade et al. (2010) studied this question.

synapsesocial.com/papers/6a72101efebe604dd70a6b60https://doi.org/10.1080/ac.65.6.2059859
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronotropic incompetence during exercise or pharmacological stress is associated with reduced survival in patients with chronic coronary syndromes2025 · 5 citations
  2. 2Chronotropic incompetence during exercise or pharmacological stress is associated with survival in patients with chronic coronary syndromes2025
  3. 3Chronotropic incompetence in patients in exercise-based cardiac rehabilitation2025
  4. 4Echocardiographic Predictors of Chronotropic Incompetence to Exercise in Patients with Heart Failure with Preserved Ejection Fraction2014 · 2 citations
  5. 5Exercise chronotropic incompetence phenotypes the level of cardiovascular risk and exercise gas exchange impairment in the general population. An analysis of the Euro-EX prevention trial2019 · 34 citations