Population
599 apparently healthy individuals with at least one major cardiovascular risk factor who achieved a…
Comparison
Presence of chronotropic insufficiency during… vs Absence of chronotropic insufficiency (no-CI)
Design
Cohort
Key result
In apparently healthy subjects with cardiovascular risk factors, lower peak VO2 independently predicted the presence of exercise chronotropic insufficiency (OR 0.91; 95% CI 0.85-0.97; p<0.05).
Authors
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Chronotropic insufficiency may mark higher risk factor burden in at-risk adults; leaves open its independent prognostic role and need for intervention trials.
Cross-Sectional (n=599)
Odds Ratio: 0.91 (95% CI 0.85–0.97)
p-value: p=<0.05
In apparently healthy individuals with cardiovascular risk factors, exercise chronotropic insufficiency is common and correlates with the number of risk factors, lower peak VO2, and abnormal echocardiographic measures.
Laforgia et al. (2019) conducted a cross-sectional in Cardiovascular risk (n=599). Chronotropic insufficiency vs. No chronotropic insufficiency was evaluated on Prediction of chronotropic insufficiency by peak VO2 (OR 0.91, 95% CI 0.85-0.97, p=<0.05). In apparently healthy subjects with cardiovascular risk factors, lower peak VO2 independently predicted the presence of exercise chronotropic insufficiency (OR 0.91; 95% CI 0.85-0.97; p<0.05).