Key result
Myocardial early diastolic velocity at the septal mitral annulus (E' septal) independently predicted chronotropic incompetence in patients with HFpEF (β 3.697).
Why the study?
Do echocardiographic parameters of diastolic dysfunction predict chronotropic incompetence to exercise in patients with HFpEF?
Population
143 consecutive patients with unexplained dyspnea and/or exercise intolerance fulfilling clinical and…
Comparison
Echocardiographic assessment of diastolic… vs Patients without chronotropic incompetence
Design
Cross-sectional
Authors
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Echocardiographic assessment may identify HFpEF patients prone to chronotropic incompetence; leaves open causal links and therapeutic implications.
Cross-Sectional (n=143)
Yes
Do echocardiographic parameters of diastolic dysfunction predict chronotropic incompetence to exercise in patients with HFpEF?
Effect estimate: β 3.697 (95% CI 0.921-6.473)
p-value: p=0.009
In patients with HFpEF, chronotropic incompetence during exercise is frequent and can be independently predicted by echocardiographic parameters of elevated LV filling pressures, such as lower E' septal velocity, along with clinical factors like beta-blocker use and smoking.
Hristovski et al. (2014) conducted a cross-sectional in Heart failure with preserved ejection fraction (HFpEF) (n=143). Echocardiographic assessment (E' septal) was evaluated on Chronotropic incompetence represented by percentage of heart rate reserve (%HRR) (β 3.697, 95% CI 0.921-6.473, p=0.009). Myocardial early diastolic velocity at the septal mitral annulus (E' septal) independently predicted chronotropic incompetence in patients with HFpEF (β 3.697).
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