Observational analysis reveals S. mansoni egg antigens impact metabolic pathways in hepatocytes and enterocytes, suggesting significant host-cell interactions.
Background: Schistosomiasis is a parasitic disease that affects more than 250 million individuals worldwide. Compelling evidence suggests that schistosome eggs, rather than adult worms, are responsible for significant tissue damage. S. mansoni eggs induce metabolic exhaustion and redox imbalance, which are critical for the integrity of hepatocellular DNA. However, the precise mechanism by which egg antigens transmit signals into host cells remains unclear. In this study, we investigated whether S. mansoni egg antigens regulate the metabolic pathways of hepatocytes and enterocytes through the insulin/insulin-like-growth-factor-receptor-1(IGF-1) receptor.
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Wald et al. (2025) studied this question.
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