Experimental analysis demonstrates exacerbated hepatic damage and autophagy dysregulation in HBsAg-transgenic mice, indicating S. mansoni's severe effects.
Background: Schistosomiasis, a parasitic helminth infection, affects over 250 million people worldwide. Blood-borne S. mansoni eggs either penetrate the gut wall to migrate into the lumen, or become trapped in blood capillaries such as liver sinusoids.
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Kuisat et al. (2025) studied this question.
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