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Observational analysis shows altered cytokine profiles in inflamed intestinal regions of ulcerative colitis patients, suggesting local production differs from plasma measurements.
Background: Proinflammatory cytokines identified in the mucosal microenvironment at the site of inflammation are involved in the pathophysiology of inflammatory bowel diseases such as ulcerative colitis (UC). We hypothesize that the local cytokine production is significantly altered in inflamed regions of the intestine and cannot be predicted by plasma measurements.
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Rogoll et al. (2025) studied this question.
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